Pagkakaiba sa pagitan ng mga pagbago ng "Marijuana"

walang buod ng pagbabago
{{Infobox botanical product
Ang ''cannabidiol'' na nasa marijuana ay mayroong epektong ''pleiotropic'' na nangangahulugang ang epekto nito ay maaring iba-iba at {{Infobox botanical product
|product =Cannabis
|image = [[File:Cannabis Plant.jpg|180px]]
Ang ''cannabidiol,'' isa sa 104 na iba't-ibang kemikal na nasa marijuana, ay mayroong epektong ''pleiotropic'' na nangangahulugang ang epekto nito ay maaring iba-iba sa bawat isang tao<ref>''"[ What is CBD?]" Canna Finest.'' Hinango noong 29 Abril 2019.</ref>. <ref>''"[ CBD Oil Effects in Humans.]" CBD Oil 360.'' Hinango noong 23 Enero 2019.</ref> Ang mga kanais nais na epekto nito ay relaksasyon at katamtamang ''euphoria'' (pakiramdam na "high"). Ang mga hindi kanais nais na epekto nito ang nabawasang panandaliang memorya, tuyong bibig, huminang kakayahan ng paggalaw, pamumula ng mga mata.
Kabilang din sa mga epekto ang pagbilis nang tibok ng puso, mataas na gana sa pagkain, at pagbaba nang presyon ng dugo.
[[Major depressive disorder|depression]],<ref name="depression">{{Cite journal|author=Bambico FR, Katz N, Debonnel G, Gobbi G |title=Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex |journal=The Journal of Neuroscience |volume=27 |issue=43 |pages=11700–11 |year=2007 |pmid=17959812 |doi=10.1523/JNEUROSCI.1636-07.2007 |laysummary=,2933,304996,00.html |laysource=[[Fox News Channel]] |laydate=25 October 2007}}</ref><ref>{{Cite journal|author=Denson TF, Earleywine M |title=Decreased depression in marijuana users |journal=Addictive Behaviors |volume=31 |issue=4 |pages=738–42 |year=2006 |pmid=15964704 |doi=10.1016/j.addbeh.2005.05.052 |url=}}</ref><ref name="Zhang_etal">{{Cite journal|author=Jiang W |title=Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects |journal=The Journal of Clinical Investigation |volume=115 |issue=11 |pages=3104–16 |year=2005 |pmid=16224541 |pmc=1253627 |doi=10.1172/JCI25509 |author2=Zhang Y |author3=Xiao L |last4=Van Cleemput |first4=J |last5=Ji |first5=SP |last6=Bai |first6=G |last7=Zhang |first7=X}}</ref><ref>{{Cite journal|author=El-Remessy AB, Al-Shabrawey M, Khalifa Y, Tsai NT, Caldwell RB, Liou GI |title=Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes |journal=The American Journal of Pathology |volume=168 |issue=1 |pages=235–44 |year=2006 |pmid=16400026 |pmc=1592672 |doi=10.2353/ajpath.2006.050500}}</ref> [[dystonia]],<ref>{{Cite journal|author=Fox SH, Kellett M, Moore AP, Crossman AR, Brotchie JM |title=Randomised, double-blind, placebo-controlled trial to assess the potential of cannabinoid receptor stimulation in the treatment of dystonia |journal=Movement Disorders |volume=17 |issue=1 |pages=145–9 |year=2002 |pmid=11835452 |doi=10.1002/mds.1280}}</ref> [[epilepsy]],<ref name="ep">{{cite news|url= |title=Cannabis could be used to treat epilepsy |work=The Daily Telegraph |date=10 April 2011 |accessdate=2011-04-20 |first=Richard |last=Gray}}</ref><ref>{{Cite journal|author=Marsicano G |title=CB1 cannabinoid receptors and on-demand defense against excitotoxicity |journal=Science |volume=302 |issue=5642 |pages=84–8 |year=2003 |pmid=14526074 |doi=10.1126/science.1088208 |last12=Casanova |first12=E |last13=Schütz |first13=G |first14=W |first15=V |first16=C |first17=B|author2=Goodenough S|author3=Monory K |last4=Zieglgänsberger |last5=Di Marzo |last6=Behl |last7=Lutz|first4=H|first5=M|first6=A|first7=SC|last8=Cascio|first8=MG|last9=Gutiérrez|first9=SO |bibcode = 2003Sci...302...84M }}</ref><ref>{{Cite journal|author=Bacci A, Huguenard JR, Prince DA |title=Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids |journal=Nature |volume=431 |issue=7006 |pages=312–6 |year=2004 |pmid=15372034 |doi=10.1038/nature02913 |laysummary= |laysource=[[Science Daily]] |laydate=16 September 2004|bibcode = 2004Natur.431..312B }}</ref> [[digestive disease]]s,<ref>{{Cite journal|author=Di Carlo G, Izzo AA |title=Cannabinoids for gastrointestinal diseases: potential therapeutic applications |journal=Expert Opinion on Investigational Drugs |volume=12 |issue=1 |pages=39–49 |year=2003 |pmid=12517253 |doi=10.1517/13543784.12.1.39}}</ref> [[glioma]]s,<ref>{{Cite journal|author=Lorente M |title=Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis |journal=Glia |volume= 57|issue= 13|pages=1374–85 |year=2009 |pmid=19229996 |doi=10.1002/glia.20856|author2=Carracedo A|author3=Torres S|last4=Natali|first4=Francesco|last5=Egia|first5=Ainara|last6=Hernández-Tiedra|first6=Sonia|last7=Salazar|first7=María|last8=Blázquez|first8=Cristina|last9=Guzmán|first9=Manuel}}</ref><ref>{{Cite journal|author=Ramer R, Hinz B |title=Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1 |journal=Journal of the National Cancer Institute |volume=100 |issue=1 |pages=59–69 |year=2008 |pmid=18159069 |doi=10.1093/jnci/djm268}}</ref> [[hepatitis C]],<ref>{{Cite journal|author=Sylvestre DL, Clements BJ, Malibu Y |title=Cannabis use improves retention and virological outcomes in patients treated for hepatitis C |journal=European Journal of Gastroenterology & Hepatology |volume=18 |issue=10 |pages=1057–63 |year=2006 |pmid=16957511 |doi=10.1097/01.meg.0000216934.22114.51}}</ref> [[Huntington's disease]],<ref>{{cite pmid|19228180}}</ref><ref>{{cite pmid|20590577}}</ref> [[leukemia]],<ref>{{Cite journal|author=Powles T |title=Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway |journal=Blood |volume=105 |issue=3 |pages=1214–21 |year=2005 |pmid=15454482 |doi=10.1182/blood-2004-03-1182 |author2=te Poele R|author3=Shamash J|last4=Chaplin|first4=T|last5=Propper|first5=D|last6=Joel|first6=S|last7=Oliver|first7=T|last8=Liu|first8=WM}}</ref> [[tumor|skin tumors]],<ref>{{Cite journal|author=Casanova ML |title=Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors |journal=The Journal of Clinical Investigation |volume=111 |issue=1 |pages=43–50 |year=2003 |pmid=12511587 |pmc=151833 |doi=10.1172/JCI16116 |author2=Blázquez C|author3=Martínez-Palacio J|last4=Villanueva|first4=Concepción|last5=Fernández-Aceñero|first5=M. Jesús|last6=Huffman|first6=John W.|last7=Jorcano|first7=José L.|last8=Guzmán|first8=Manuel}}</ref> [[Methicillin-resistant Staphylococcus aureus|methicillin-resistant ''Staphylococcus aureus'']] (MRSA),<ref>{{Cite journal|author=Appendino G, Gibbons S, Giana A, Pagani A, Grassi G, Stavri M, Smith E, Rahman MM |title=Antibacterial Cannabinoids from ''Cannabis sativa'': A Structure—Activity Study |journal=J Nat Prod |volume=71 |issue=8 |pages=1427–30 |year=2008|pmid=18681481 |doi=10.1021/np8002673 |laysummary= |laysource=[[WebMD]] |laydate=4 September 2008 |accessdate=6 November 2010}}</ref> [[Parkinson's disease]],<ref>{{Cite journal|author=Kreitzer AC, Malenka RC |title=Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models |journal=Nature |volume=445 |issue=7128 |pages=643–7 |year=2005 |pmid=17287809 |doi=10.1038/nature05506 |laysummary= |laysource=[[Stanford University School of Medicine]] |laydate=7 February 2007}}</ref> [[Itch|pruritus]],<ref>{{Cite journal|author=Szepietowski JC, Szepietowski T, Reich A |title=Efficacy and tolerance of the cream containing structured physiological lipids with endocannabinoids in the treatment of uremic pruritus: a preliminary study |journal=Acta Dermatovenerologica Croatica |volume=13 |issue=2 |pages=97–103 |year=2005 |pmid=16324422}}</ref><ref>{{Cite journal|author=Bergasa NV |title=The pruritus of cholestasis |journal=Journal of Hepatology |volume=43 |issue=6 |pages=1078–88 |year=2005 |pmid=16253381 |doi=10.1016/j.jhep.2005.09.004}}</ref> [[posttraumatic stress disorder]] (PTSD),<ref>{{Cite journal|author=Ganon-Elazar E, Akirav I|title=Cannabinoid receptor activation in the basolateral amygdala blocks the effects of stress on the conditioning and extinction of inhibitory avoidance|journal=J. Neurosci|volume=29|issue=36|pages=11078–88|pmid=19741114 |year=2009|laysummary=|laysource=PsychCentral|laydate=5 November 2009|doi=10.1523/JNEUROSCI.1223-09.2009}}</ref> [[psoriasis]],<ref>{{cite pmid|17157480}}</ref> [[sickle-cell disease]],<ref>{{cite pmid|16173972}}</ref> [[sleep apnea]],<ref>{{Cite journal|author=Carley DW, Paviovic S, Janelidze M, Radulovacki M |title=Functional role for cannabinoids in respiratory stability during sleep |journal=Sleep |volume=25 |issue=4 |pages=391–8 |year=2002 |pmid=12071539 |url= }}</ref> at [[anorexia nervosa]].<ref>Grotenhermen, Russo (2002) "Review of Therapeutic Effects." Chapter 11, p. 128 in ''Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential'', Routledge, ISBN 0789015080.</ref>
===Epekto sa kanser===
Natagpuan ng isang pag-aaral ng [[Universidad Complutense de Madrid]] na ang mga kimikalkemikal sa marijuana ay nagsanhi ng kamatayan ng mga selulang [[kanser ng utak]] ng tao. Sa mga selulang kanser ng utak ng tao na nilagay sa mga daga na ginamot ng kemikal ng marijuana, ang tumor ay lumiit. Natagpuan ng pag-aaral nila na ang THC ay nag-alis ng mga selulang kanser nang walang masamang epekto sa mga malulusog na selula. <ref name=pmid19425170>{{Cite journal|author=Salazar M |title=Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells |journal=The Journal of Clinical Investigation |volume=119 |issue=5 |pages=1359–72 |year=2009|pmid=19425170 |pmc=2673842 |doi=10.1172/JCI37948 |laysummary= |laysource=[[HealthDay]] |laydate=1 April 2009 |last12=Fimia |first12=GM |last13=Piacentini |first13=M |first14=F |first15=PP |first16=L |first17=JL |first18=M |first19=P |last20=Velasco |first20=G|author2=Carracedo A|author3=Salanueva IJ |last4=Cecconi |last5=Pandolfi |last6=González-Feria |last7=Iovanna |last8=Guzmán |last9=Boya |first4=Sonia |first5=Mar |first6=Ainara |first7=Patricia |first8=Cristina |first9=Sofía}}</ref>
Ayon sa pag-aaral ng [[California Pacific Medical Center]] Research Institute noong 2007 at 2010, ang [[cannabidiol]] ay nagpahinto sa [[kanser sa suso]] na kumalat na sa buong katawan sa pamamagitan ng ''downregulation'' ng isang ''gene'' na tinatawag na [[ID1]].<ref name=pmid18025276>{{Cite journal|author=McAllister SD, Christian RT, Horowitz MP, Garcia A, Desprez PY |title=Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells |journal=Molecular Cancer Therapeutics |volume=6 |issue=11 |pages=2921–7 |year=2007 |pmid=18025276 |doi=10.1158/1535-7163.MCT-07-0371 |laysummary= |laysource=[[BBC News]] |laydate=19 November 2007}}</ref>