Noong 1994, kinasal siya sa aktor na si [[Alexis Ayala]]<ref>[http://www.latintimes.com/articles/10319/20131116/karla-alvarez-death-father-husband-alexis-ayala-react-respond-family-dead-died.htm Karla Alvarez Death: Ex Husband Alexis Ayala, Father React To Mexican Actress Tragically Taken Too Soon] (sa Ingles)</ref> at noong 1995 inihayag na naghiwalay sila. Kinasal siya muli kay Antonio D’Agostino.<ref>[http://www.latintimes.com/articles/10640/20131126/karla-alvarez-death-actress-filed-divorce-antonio-d-agostino-domestic-abuse.htm Karla Alvarez death actress filed divorce Antonio D'Agostino domestic abuse] (sa Ingles)</ref><ref>[http://www.latintimes.com/articles/10380/20131118/karla-alvarez-death-actress-suing-husband-antonio.htm Karla Alvarez death actress suing husband Antonio] (sa Ingles)</ref><ref>[http://guardianlv.com/2013/11/karla-alvarez-was-suing-dagostino-court-papers-show/ Karla Alvarez was suing D'Agostino court papers show] (sa Ingles)</ref><ref>[http://www.latintimes.com/articles/10544/20131122/karla-alvarez-married-antonio-d-agostino-dead.htm Karla Alvarez married Antonio D'Agostino dead] (sa Ingles)</ref>
