Wikipedia

Reseptor na 5-HT

Ang mga reseptor na 5-HT (sa Ingles ay 5-hydroxytryptamine receptors o 5-HT receptors o serotonin receptors) ang pangkat ng mga pinagdugtong ng G protina na mga reseptor(G protein-coupled receptor o GPCR) at binabakuran-ng-ligandong kanelo ng ion(ligand-gated ion channels o LGIC) na matatagpuan sa sentral at periperal na sistemang nerbiyos. Ang mga ito ay tagapamagitan ng parehong nagpapanabik(excitatory) at nagpipigil(inhibitory) na neurotransmisyon. Ang mga reseptor na 5-HT ay pinapagana ng serotoninn na umaasal bilang mga natural na ligando ng mga ito.

Ang mga reseptor na 5-HT ay nangangasiwa sa paglabas ng maraming mga neurotransmitter gaya ng glutamate, GABA, dopamino(dopamine), epineprino(epinephrine) /norepineprino(norepinephrine), acetylcholine gayundin ang maraming mga hormone kabilang ang oxytocin, prolactin, vasopressin, cortisol, corticotropin at substansiyang P bukod sa iba pa. Ang mga reseptor na 5-HT ay umiimpluwensiya sa iba't ibang mga prosesong biolohikal at neurolohikal gaya ng agresyon, pagkabalisa(anxiety), gana(appetite), kognisyon, pagkatuto, memorya, damdamin(mood), nausea, pagtulog at termoregulasyon. Ang mga reseptor na 5-HT ang inaasinta(target) ng iba't ibang mga parmasyutikal at mga ilegal na droga kabilang ang antidepressant, antisikotiko, anorektiko, antiemetiko, mga ahenteng gastroprokinetiko, mga ahenteng nagpapalis ng migraine, halusiheniko, at entaktoheno. Ang mga drogang ito ay tinatawag na agonista.

Sa kabaligtaran, ang mga droga namang humaharang sa pagpapagana ng mga reseptor na 5-HT ay tinatawag na mga antagonista

Mga pamilya ng reseptor na 5-HT

baguhin
Pamilya Uri Mekanismo Potensiyal
5-HT1 pinagdugtong ng protinang-Gi/Go. Nagbabawas ng lebel sa selula ng cAMP. Nagpipigil
5-HT2 pinagdugtong ng protinang-Gq/G11. Nagdadagdag ng lebel sa selula ng IP3 and DAG. Nagpapanabik
5-HT3 Binabakuran ng ligandong Na+ at K+ na kanelong kasyon. Nagsasagawa ng depolarisasyon sa membrano ng plasma. Nagpapanabik
5-HT4 pinagdugtong ng protinang-Gs. Nagdadagdag ng lebel sa selula ng cAMP. Nagpapanabik
5-HT5 pinagdugtong ng protinang-Gi/Go.[1] Nagbabawas ng lebel sa selula ng cAMP. Nagpipigil
5-HT6 pinagdugtong ng protinang-Gs. Nagdadagdag ng lebel sa selula ng cAMP. Nagpapanabik
5-HT7 pinagdugtong ng protinang-Gs. Nagdadagdag ng lebel sa selula ng cAMP. Nagpapanabik

Mga pang-ilalim na uri

baguhin

Sa loob ng mga pangkalahatang klaseng ito ng mga reseptor na 5-HT, ang ilang mga spesipikong uri ay pinangkat ayon sa katangian ng mga ito: [2][3][4]

Buod ng mga reseptor na 5-HT
Reseptor Gene Distribusyon Tungkulin Agonista Antagonista
5-HT1A
5-HT1B
  • Blood Vessels
  • CNS
5-HT1D
  • Pagkabalisa(Anxiety)[35][36]
  • Lokomosyon[34]
  • Basokonstriksiyon
5-HT1e putative receptor
5-HT1F
  • CNS
  • Migraine
  • LY334370
  • COL-144
5-HT2A
  • Besel ng dugo
  • CNS
  • GI Tract
  • Platelet
  • PNS
  • Makinis na masel
  • Adiksiyon (potentially modulating) [37]
  • Pagkabalisa(Anxiety)[38]
  • Gana(Appetite)
  • Kognisyon
  • Imahinasyon
  • Pagkatuto
  • Memorya
  • Damdamin(Mood)
  • Persepsiyon
  • Pag-aasal na sekswal[39]
  • Tulog[40]
  • Termoregulasyon[41]
  • Vasoconstriction[42]
5-HT2B
  • Besel ng dugo
  • CNS
  • GI Tract
  • Platelets
  • PNS
  • Makinis na masel
  • Pagkabalisa(Anxiety)[43][44][45]
  • Gana(Appetite)[46]
  • Mga tungkuling kardiyobaskular
  • Motilidad na gastrointestinal[47]
  • Tulog[40]
  • Basokonstriksiyon
5-HT2C
  • Besel ng dugo
  • CNS
  • GI Tract
  • Platelet
  • PNS
  • Makinis na masel
  • Adiksiyon(Addiction). (potentially modulating)[37]
  • Pagkabalisa(Anxiety)[48][49][50]
  • Gana(Appetite)
  • Motilidad na gastrointestinal [51]
  • Lokomosyon
  • Damdamin(Mood)[49][50]
  • Ereksiyon ng titi(Penile Erection)[52][53]
  • Pag-aasal na sekswal[39]
  • Tulog[54]
  • Termoregulasyon[41]
  • Basokonstriksiyon
5-HT3
  • CNS
  • GI Tract
  • PNS
  • Adiksiyon
  • Pagkabalisa(Anxiety)
  • Emesis
  • Motilidad na gastrointestinal
  • Pagkatuto[56]
  • Memorya[56]
  • Nausea
5-HT4
  • CNS
  • GI Tract
  • PNS
5-HT5A
  • CNS
5-HT6
  • CNS
5-HT7
  • Besel ng dugo
  • CNS
  • GI Tract

Sanggunian

baguhin
  1. ↑ Francken BJ, Jurzak M, Vanhauwe JF, Luyten WH, Leysen JE. (1998). "The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells". Eur J Pharmacol. 361 (2–3): 299–309. doi:10.1016/S0014-2999(98)00744-4. PMID 9865521.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  2. ↑ Glennon RA, Dukat M, Westkaemper RB (2000-01-01). "Serotonin Receptor Subtypes and Ligands". American College of Neurophyscopharmacology. Nakuha noong 2008-04-11.{{cite web}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  3. ↑ "5-Hydroxytryptamine Receptors". IUPHAR Receptor Database. International Union of Basic and Clinical Pharmacology. Inarkibo mula sa orihinal noong 2016-06-01. Nakuha noong 2008-04-11.{{cite web}}: CS1 maint: date auto-translated (link)
  4. ↑ Wesolowska A (2002). "In the search for selective ligands of 5-HT5, 5-HT6 and 5-HT7 serotonin receptors" (PDF). Polish Journal of Pharmacology. 54 (4): 327–41. PMID 12523486.{{cite journal}}: CS1 maint: date auto-translated (link)
  5. ↑ Tomkins DM, Higgins GA, Sellers EM (1994). "Low doses of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake". Psychopharmacology (Berl). 115 (1–2): 173–9. doi:10.1007/BF02244769. PMID 7862892.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  6. ↑ Müller CP, Carey RJ, Huston JP, De Souza Silva MA (2007). "Serotonin and psychostimulant addiction: focus on 5-HT1A-receptors". Prog Neurobiol. 81 (3): 133–78. doi:10.1016/j.pneurobio.2007.01.001. PMID 17316955.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  7. ↑ Carey RJ, DePalma G, Damianopoulos E, Shanahan A, Müller CP, Huston JP (2005). "Evidence that the 5-HT1A autoreceptor is an important pharmacological target for the modulation of cocaine behavioral stimulant effects". Brain Res. 1034 (1–2): 162–71. doi:10.1016/j.brainres.2004.12.012. PMID 15713268.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  8. ↑ 8.0 8.1 de Boer SF, Koolhaas JM (2005). "5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis". Eur J Pharmacol. 526 (1–3): 125–39. doi:10.1016/j.ejphar.2005.09.065. PMID 16310183.{{cite journal}}: CS1 maint: date auto-translated (link)
  9. ↑ Parks CL, Robinson PS, Sibille E, Shenk T, Toth M (1998). "Increased anxiety of mice lacking the serotonin1A receptor". Proc Natl Acad Sci U S A. 195 (18): 10734–9. doi:10.1073/pnas.95.18.10734. PMC 27964. PMID 9724773.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  10. ↑ Ebenezer IS, Arkle MJ, Tite RM (1998). "8-Hydroxy-2-(di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors". Methods Find Exp Clin Pharmacol. 29 (4): 269–72. doi:10.1358/mf.2007.29.4.1075362. PMID 17609739.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  11. ↑ 11.0 11.1 Wouters W, Tulp MT, Bevan P (1998). "Flesinoxan lowers blood pressure and heart rate in cats via 5-HT1A receptors". Eur J Pharmacol. 149 (3): 213–23. doi:10.1016/0014-2999(88)90651-6. PMID 2842163.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  12. ↑ 12.0 12.1 Horiuchi J, McDowall LM, Dampney RA (2008). "Role of 5-HT(1A) receptors in the lower brainstem on the cardiovascular response to dorsomedial hypothalamus activation". Auton Neurosci. 142 (1–2): 71–6. doi:10.1016/j.autneu.2008.06.004. PMID 18667366.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  13. ↑ Nalivaiko E, Ootsuka Y, Blessing WW. (2005). "Activation of 5-HT1A receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and inflammatory stresses in rabbits". Am J Physiol Regul Integr Comp Physiol. 289 (2): R596–R604. doi:10.1152/ajpregu.00845.2004. PMID 15802554.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  14. ↑ 14.0 14.1 Lucot JB. (1994). "Antiemetic effects of flesinoxan in cats: comparisons with 8-hydroxy-2-(di-n-propylamino)tetralin". Eur J Pharmacol. 253 (1–2): 53–60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549.{{cite journal}}: CS1 maint: date auto-translated (link)
  15. ↑ Winstanley CA, Theobald DE, Dalley JW, Robbins TW. (2005). "Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders". Neuropsychopharmacology. 30 (4): 669–682. doi:10.1038/sj.npp.1300610. PMID 15688093.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  16. ↑ Ogren SO, Eriksson TM, Elvander-Tottie E, D'Addario C, Ekström JC, Svenningsson P, Meister B, Kehr J, Stiedl O (2008). "The role of 5-HT(1A) receptors in learning and memory". Behav Brain Res. 195 (1): 54–77. doi:10.1016/j.bbr.2008.02.023. PMID 18394726.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  17. ↑ Yasuno F, Suhara T, Nakayama T, Ichimiya T, Okubo Y, Takano A, Ando T, Inoue M, Maeda J, Suzuki K (2003). "Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory". Am J Psychiatry. 160 (2): 334–40. doi:10.1176/appi.ajp.160.2.334. PMID 12562581.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  18. ↑ Kennett GA, Dourish CT, Curzon G (1987). "Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression". Eur J Pharmacol. 134 (3): 265–74. doi:10.1016/0014-2999(87)90357-8. PMID 2883013.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  19. ↑ Bardin L, Tarayre JP, Malfetes N, Koek W, Colpaert FC. (2003). "Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain". Pharmacology. 67 (4): 182–194. doi:10.1159/000068404. PMID 12595749.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  20. ↑ 20.0 20.1 Millan MJ, Perrin-Monneyron S (1997). "Potentiation of fluoxetine-induced penile erections by combined blockade of 5-HT1A and 5-HT1B receptors". Eur J Pharmacol. 321 (3): 11–3. doi:10.1016/S0014-2999(97)00050-2. PMID 9085055.{{cite journal}}: CS1 maint: date auto-translated (link)
  21. ↑ Prow MR, Martin KF, Heal DJ (1996). "8-OH-DPAT-induced mydriasis in mice: a pharmacological characterisation". Eur J Pharmacol. 317 (1): 21–8. doi:10.1016/S0014-2999(96)00693-0. PMID 8982715.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  22. ↑ 22.0 22.1 22.2 Meyer LC, Fuller A, Mitchell D (2006). "Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 290 (2): R405–13. doi:10.1152/ajpregu.00440.2005. PMID 16166206. {{cite journal}}: Unknown parameter |month= ignored (tulong)CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  23. ↑ 23.0 23.1 Popova NK, Amstislavskaya TG (2002). "Involvement of the 5-HT(1A) and 5-HT(1B) serotonergic receptor subtypes in sexual arousal in male mice". Psychoneuroendocrinology. 27 (5): 609–18. doi:10.1016/S0306-4530(01)00097-X. PMID 11965359.{{cite journal}}: CS1 maint: date auto-translated (link)
  24. ↑ Monti JM, Jantos H (1992). "Dose-dependent effects of the 5-HT1A receptor agonist 8-OH-DPAT on sleep and wakefulness in the rat". J Sleep Res. 1 (3): 169–175. doi:10.1111/j.1365-2869.1992.tb00033.x. PMID 10607047.{{cite journal}}: CS1 maint: date auto-translated (link)
  25. ↑ Thompson MR, Callaghan PD, Hunt GE, Cornish JL, McGregor IS (2007). "A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy")". Neuroscience. 146 (2): 509–14. doi:10.1016/j.neuroscience.2007.02.032. PMID 17383105.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  26. ↑ Gudelsky GA, Koenig JI, Meltzer HY (1986). "Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors". Neuropharmacology. 25 (12): 1307–13. doi:10.1016/0028-3908(86)90101-2. PMID 2951611.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  27. ↑ Ootsuka Y, Blessing WW. (2006). "Activation of 5-HT1A receptors in rostral medullary raphé inhibits cutaneous vasoconstriction elicited by cold exposure in rabbits". Brain Res. 1073–1074: 252–61. doi:10.1016/j.brainres.2005.12.031. PMID 16455061.{{cite journal}}: CS1 maint: date auto-translated (link)
  28. ↑ 28.00 28.01 28.02 28.03 28.04 28.05 28.06 28.07 28.08 28.09 28.10 28.11 28.12 28.13 28.14 28.15 28.16 28.17 28.18 28.19 pharmamotion.com > Serotonin (5-HT): receptors, agonists and antagonists Naka-arkibo 2009-09-15 sa Wayback Machine. By Flavio Guzmán, M.D. on 9/08/09
  29. ↑ Harrison AA, Parsons LH, Koob GF, Markou A (1999). "RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist". Psychopharmacology (Berl). 141 (3): 242–50. doi:10.1007/s002130050831. PMID 10027505.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  30. ↑ Chojnacka-Wójcik E, Klodzinska A, Tatarczynska E (2005). "The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action". J Pharm Pharmacol. 57 (2): 253–7. doi:10.1211/0022357055399. PMID 15720791.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  31. ↑ Lin D, Parsons LH (2002). "Anxiogenic-like effect of serotonin(1B) receptor stimulation in the rat elevated plus-maze". Pharmacol Biochem Behav. 71 (4): 581–7. doi:10.1016/S0091-3057(01)00712-2. PMID 11888549.{{cite journal}}: CS1 maint: date auto-translated (link)
  32. ↑ 32.0 32.1 Tatarczynska E, Klodzinska A, Stachowicz K, Chojnacka-Wójcik E (2004). "Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression". Behav Pharmacol. 15 (8): 523–34. doi:10.1097/00008877-200412000-00001. PMID 15577451.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  33. ↑ 33.0 33.1 Eriksson TM, Madjid N, Elvander-Tottie E, Stiedl O, Svenningsson P, Ogren SO (2008). "Blockade of 5-HT 1B receptors facilitates contextual aversive learning in mice by disinhibition of cholinergic and glutamatergic neurotransmission". Neuropharmacology. 54 (7): 1041–50. doi:10.1016/j.neuropharm.2008.02.007. PMID 18394658.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  34. ↑ 34.0 34.1 McCreary AC, Bankson MG, Cunningham KA (1999). "Pharmacological studies of the acute and chronic effects of (+)-3, 4-methylenedioxymethamphetamine on locomotor activity: role of 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B/1D) receptors". J Pharmacol Exp Ther. 290 (3): 965–73. PMID 10454466.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  35. ↑ Amital D, Fostick L, Sasson Y, Kindler S, Amital H, Zohar J (2005). "Anxiogenic effects of Sumatriptan in panic disorder: a double-blind, placebo-controlled study". Eur Neuropsychopharmacol. 15 (3): 279–82. doi:10.1016/j.euroneuro.2004.12.002. PMID 15820416.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  36. ↑ Feuerstein TJ, Hüring H, van Velthoven V, Lücking CH, Landwehrmeyer GB (1996). "5-HT1D-like receptors inhibit the release of endogenously formed [3H]GABA in human, but not in rabbit, neocortex". Neurosci Lett. 209 (3): 210–4. doi:10.1016/0304-3940(96)12637-9. PMID 8736648.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  37. ↑ 37.0 37.1 [1] Bubar MJ, Cunningham KA. Serotonin 5-HT2A and 5-HT2C receptors as potential targets for modulation of psychostimulant use and dependence. Curr Top Med Chem. 2006;6(18):1971-85.
  38. ↑ Schreiber R, Melon C, De Vry J (1998). "The role of 5-HT receptor subtypes in the anxiolytic effects of selective serotonin reuptake inhibitors in the rat ultrasonic vocalization test". Psychopharmacology (Berl). 135 (4): 383–91. doi:10.1007/s002130050526. PMID 9539263.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  39. ↑ 39.0 39.1 Popova NK, Amstislavskaya TG (2002). "5-HT2A and 5-HT2C serotonin receptors differentially modulate mouse sexual arousal and the hypothalamo-pituitary-testicular response to the presence of a female". Neuroendocrinology. 76 (1): 28–34. doi:10.1159/000063681. PMID 12097814.{{cite journal}}: CS1 maint: date auto-translated (link)
  40. ↑ 40.0 40.1 Popa D, Léna C, Fabre V, Prenat C, Gingrich J, Escourrou P, Hamon M, Adrien J (2005). "Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors". J Neurosci. 25 (49): 11231–8. doi:10.1523/JNEUROSCI.1724-05.2005. PMID 16339018.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  41. ↑ 41.0 41.1 Mazzola-Pomietto P, Aulakh CS, Tolliver T, Murphy DL (1997). "Functional subsensitivity of 5-HT2A and 5-HT2C receptors mediating hyperthermia following acute and chronic treatment with 5-HT2A/2C receptor antagonists". Psychopharmacology (Berl). 130 (2): 144–51. doi:10.1007/s002130050222. PMID 9106912.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  42. ↑ Blessing WW, Seaman B. (2003). "5-hydroxytryptamine(2A) receptors regulate sympathetic nerves constricting the cutaneous vascular bed in rabbits and rats". Neuroscience. 117 (4): 939–948. doi:10.1016/S0306-4522(02)00810-2. PMID 12654345.{{cite journal}}: CS1 maint: date auto-translated (link)
  43. ↑ Kennett GA, Bright F, Trail B, Baxter GS, Blackburn TP (1996). "Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety". Br J Pharmacol. 117 (7): 1443–8. PMC 1909458. PMID 8730737.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  44. ↑ Duxon MS, Kennett GA, Lightowler S, Blackburn TP, Fone KC (1997). "Activation of 5-HT2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat". Neuropharmacology. 36 (4–5): 601–8. doi:10.1016/S0028-3908(97)00042-7. PMID 9225285.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  45. ↑ Kennett GA, Trail B, Bright F (1998). "Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated". Neuropharmacology. 37 (12): 1603–10. doi:10.1016/S0028-3908(98)00115-4. PMID 9886683.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  46. ↑ Kennett GA, Ainsworth K, Trail B, Blackburn TP (1997). "BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats". Neuropharmacology. 36 (2): 233–9. doi:10.1016/S0028-3908(96)00171-2. PMID 9144661.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  47. ↑ Borman RA, Tilford NS, Harmer DW, Day N, Ellis ES, Sheldrick RL, Carey J, Coleman RA, Baxter GS. (2002). "5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro". Br J Pharmacol. 135 (5): 1144–1151. doi:10.1038/sj.bjp.0704571. PMC 1573235. PMID 11877320.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  48. ↑ Kennett GA, Wood MD, Bright F, Trail B, Riley G, Holland V, Avenell KY, Stean T, Upton N, Bromidge S, Forbes IT, Brown AM, Middlemiss DN, Blackburn TP (1997). "SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist". Neuropharmacology. 36 (4–5): 609–20. doi:10.1016/S0028-3908(97)00038-5. PMID 9225286.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  49. ↑ 49.0 49.1 Millan MJ, Brocco M, Gobert A, Dekeyne A (2005). "Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade". Psychopharmacology (Berl). 177 (4): 448–58. doi:10.1007/s00213-004-1962-z. PMID 15289999.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  50. ↑ 50.0 50.1 Millan MJ, Brocco M, Gobert A, Dekeyne A (2008). "S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models". Psychopharmacology (Berl). 199 (4): 549–68. doi:10.1007/s00213-008-1177-9. PMID 18523738.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  51. ↑ Fujitsuka N, Asakawa A, Hayashi M, Sameshima M, Amitani H, Kojima S, Fujimiya M, Inui A. (2009). "Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl ghrelin". Biol Psychiatry. 65 (9): 748–759. doi:10.1016/j.biopsych.2008.10.031. PMID 19058784.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
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  54. ↑ Frank MG, Stryker MP, Tecott LH (2002). "Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor". Neuropsychopharmacology. 27 (5): 869–73. doi:10.1016/S0893-133X(02)00353-6. PMC 2452994. PMID 12431861.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  55. ↑ Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4.{{cite book}}: CS1 maint: date auto-translated (link) Page 187
  56. ↑ 56.0 56.1 Pitsikas N, Brambilla A, Borsini F. (1994). "Effect of DAU 6215, a novel 5-HT3 receptor antagonist, on scopolamine-induced amnesia in the rat in a spatial learning task". Pharmacol Biochem Behav. 47 (1): 95–99. doi:10.1016/0091-3057(94)90116-3. PMID 8115433.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  57. ↑ 57.0 57.1 Smriga M, Torii K (2003). "L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats". Proc Natl Acad Sci U S A. 100 (26): 15370–5. doi:10.1073/pnas.2436556100. PMC 307574. PMID 14676321.{{cite journal}}: CS1 maint: date auto-translated (link)
  58. ↑ Kennett GA, Bright F, Trail B, Blackburn TP, Sanger GJ (1997). "Anxiolytic-like actions of the selective 5-HT4 receptor antagonists SB 204070A and SB 207266A in rats". Neuropharmacology. 36 (4–5): 707–12. doi:10.1016/S0028-3908(97)00037-3. PMID 9225297.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  59. ↑ Jean A, Conductier G, Manrique C, Bouras C, Berta P, Hen R, Charnay Y, Bockaert J, Compan V (2007). "Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens". Proc Natl Acad Sci U S A. 104 (41): 16335–40. doi:10.1073/pnas.0701471104. PMC 2042207. PMID 17913892.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  60. ↑ J Soc Biol.; Charnay, Y; Dusticier, N; Daszuta, A; Hen, R; Bockaert, J (2004). "Compan V, Charnay Y, Dusticier N, Daszuta A, Hen R, Bockaert J". J Soc Biol. 198 (1): 37–49. PMID 15146954.{{cite journal}}: CS1 maint: date auto-translated (link)
  61. ↑ 61.0 61.1 Meneses A, Hong E (1997). "Effects of 5-HT4 receptor agonists and antagonists in learning". Pharmacol Biochem Behav. 56 (3): 347–51. doi:10.1016/S0091-3057(96)00224-9. PMID 9077568.{{cite journal}}: CS1 maint: date auto-translated (link)
  62. ↑ 62.0 62.1 Fontana DJ, Daniels SE, Wong EH, Clark RD, Eglen RM (1997). "The effects of novel, selective 5-hydroxytryptamine (5-HT)4 receptor ligands in rat spatial navigation". Neuropharmacology. 36 (4–5): 689–96. doi:10.1016/S0028-3908(97)00055-5. PMID 9225295.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  63. ↑ Fontana DJ, Daniels SE, Wong EH, Clark RD, Eglen RM (1998). "Role of 5-HT4 receptors in the mouse passive avoidance test". J Pharmacol Exp Ther. 286 (3): 1115–21. PMID 9732367.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  64. ↑ Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G (2007). "Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action". Neuron. 55 (5): 679–81. doi:10.1016/j.neuron.2007.07.041. PMID 17785179.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  65. ↑ Duman RS; Rymar, VV; Du, J; Mnie-Filali, O; Bisgaard, C; Manta, S; Lambas-Senas, L; Wiborg, O; Haddjeri, N (2007). "A silver bullet for the treatment of depression?". Neuron. 55 (5): 712–25. doi:10.1016/j.neuron.2007.08.011. PMID 17785173.{{cite journal}}: CS1 maint: date auto-translated (link)
  66. ↑ Manzke T, Guenther U, Ponimaskin E, Haller M, Dutschmann M, Schwarzacher S, Richter D (2003). "5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia". Science. 301 (5630): 226–9. doi:10.1126/science.1084674. PMID 12855812.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  67. ↑ Nelson DL (2004). "5-HT5 receptors". Curr Drug Targets CNS Neurol Disord. 3 (1): 53–8. doi:10.2174/1568007043482606. PMID 14965244.{{cite journal}}: CS1 maint: date auto-translated (link)
  68. ↑ 68.0 68.1 Dietz BM, Mahady GB, Pauli GF, Farnsworth NR (2005). "Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro". Brain Res Mol Brain Res. 138 (2): 191–7. doi:10.1016/j.molbrainres.2005.04.009. PMID 15921820.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  69. ↑ Wesolowska A (2008). "The anxiolytic-like effect of the selective 5-HT6 receptor antagonist SB-399885: the impact of benzodiazepine receptors". European Journal of Pharmacology. 580 (3): 355–60. doi:10.1016/j.ejphar.2007.11.022. PMID 18096153. {{cite journal}}: Unknown parameter |month= ignored (tulong)CS1 maint: date auto-translated (link)
  70. ↑ 70.0 70.1 Wesolowska A, Nikiforuk A (2007). "Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression". Neuropharmacology. 52 (5): 1274–83. doi:10.1016/j.neuropharm.2007.01.007. PMID 17320917. {{cite journal}}: Unknown parameter |month= ignored (tulong)CS1 maint: date auto-translated (link)
  71. ↑ Hirst WD, Stean TO, Rogers DC, Sunter D, Pugh P, Moss SF, Bromidge SM, Riley G, Smith DR, Bartlett S, Heidbreder CA, Atkins AR, Lacroix LP, Dawson LA, Foley AG, Regan CM, Upton N (2006). "SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models". European Journal of Pharmacology. 553 (1–3): 109–19. doi:10.1016/j.ejphar.2006.09.049. PMID 17069795. {{cite journal}}: Unknown parameter |month= ignored (tulong)CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  72. ↑ 72.0 72.1 Perez-García G, Meneses A (2005). "Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task". Pharmacology, Biochemistry, and Behavior. 81 (3): 673–82. doi:10.1016/j.pbb.2005.05.005. PMID 15964617. {{cite journal}}: Unknown parameter |month= ignored (tulong)CS1 maint: date auto-translated (link)
  73. ↑ Wesolowska A, Nikiforuk A (2008). "The selective 5-HT(6) receptor antagonist SB-399885 enhances anti-immobility action of antidepressants in rats". European Journal of Pharmacology. 582 (1–3): 88–93. doi:10.1016/j.ejphar.2007.12.013. PMID 18234190. {{cite journal}}: Unknown parameter |month= ignored (tulong)CS1 maint: date auto-translated (link)
  74. ↑ "Target Schizophrenia - Possible future developments". The Association of the British Pharmaceutical Industry. Inarkibo mula sa orihinal noong 2008-06-12. Nakuha noong 2008-04-11.{{cite web}}: CS1 maint: date auto-translated (link)
  75. ↑ 75.0 75.1 75.2 Hedlund PB, Huitron-Resendiz S, Henriksen SJ, Sutcliffe JG (2005). "5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern". Biological Psychiatry. 58 (10): 831–7. doi:10.1016/j.biopsych.2005.05.012. PMID 16018977. {{cite journal}}: Unknown parameter |month= ignored (tulong)CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  76. ↑ 76.0 76.1 Wesolowska A, Nikiforuk A, Stachowicz K, Tatarczynska E (2006). "Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression". Neuropharmacology. 51 (3): 578–86. doi:10.1016/j.neuropharm.2006.04.017. PMID 16828124. {{cite journal}}: Unknown parameter |month= ignored (tulong)CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  77. ↑ Gasbarri A, Cifariello A, Pompili A, Meneses A (2008). "Effect of 5-HT(7) antagonist SB-269970 in the modulation of working and reference memory in the rat". Behavioural Brain Research. 195 (1): 164–70. doi:10.1016/j.bbr.2007.12.020. PMID 18308404. {{cite journal}}: Unknown parameter |month= ignored (tulong)CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  78. ↑ Liy-Salmeron G, Meneses A (2008). "Effects of 5-HT drugs in prefrontal cortex during memory formation and the ketamine amnesia-model". Hippocampus. 18 (9): 965–74. doi:10.1002/hipo.20459. PMID 18570192.{{cite journal}}: CS1 maint: date auto-translated (link)
  79. ↑ 79.0 79.1 Bonaventure P, Kelly L, Aluisio L, Shelton J, Lord B, Galici R, Miller K, Atack J, Lovenberg TW, Dugovic C (2007). "Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents". J Pharmacol Exp Ther. 321 (2): 690–8. doi:10.1124/jpet.107.119404. PMID 17314195.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)
  80. ↑ Thomas DR, Melotto S, Massagrande M, Gribble AD, Jeffrey P, Stevens AJ, Deeks NJ, Eddershaw PJ, Fenwick SH, Riley G, Stean T, Scott CM, Hill MJ, Middlemiss DN, Hagan JJ, Price GW, Forbes IT (2003). "SB-656104-A, a novel selective 5-HT7 receptor antagonist, modulates REM sleep in rats". Br J Pharmacol. 139 (4): 705–14. doi:10.1038/sj.bjp.0705290. PMC 1573887. PMID 12812993.{{cite journal}}: CS1 maint: date auto-translated (link) CS1 maint: multiple names: mga may-akda (link)

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